Frontiers of Redox Biology

Takaaki Akaike, Beatriz Alvarez, Ruma Banerjee, Clive Yik-Sham Chung, Tobias P. Dick, Cristina Furdui, Mark Hampton, Elena Hidalgo, Gerta Hoxhaj, Carola Neumann, Pablo Rivera-Fuentes, Eranthie Weerapana, Ming Xian, Nat. Chem. Biol.2026, 22, 517–519.

A Ratiometric pH Sensor for Gram-positive and Gram-negative Bacteria

D. Kossmann, A. Iizuka, N. Khanna, P. Rivera-Fuentes, J. Am. Chem. Soc. 2026, 148, 4754–4765.

Two-Color Timestamping of Gene Expression with a Chemigenetic Reporter System

H. Lämmermann, J. Nguyen, J. F. Tamez-Fernández, F. Kuttler, J. Bortoli Chapalay, M. Chambon, G. Turcatti, P. Rivera-Fuentes, ChemBioChem2025, 26, e202500494

Potent Inducers of Paraptosis through Electronic Tuning of Hemicyanine Electrophiles

J. F. Tamez-Fernández, C. F. Steven, J. Nguyen, P. Rivera-Fuentes, J. Am. Chem. Soc. 2025, 147, 32571–32579.

Fluorescence Lifetime Multiplexing with Environment-Sensitive Chemigenetic Probes

S. Emmert, A. Rovira, P. Rivera-Fuentes, ChemBioChem2025, 26, e202500174.

Characterization of the Glutathione Redox State in the Golgi Apparatus

C. Miró-Vinyals, S. Emmert, G. Grammbitter, A. Jud, T. Kockmann, P. Rivera-Fuentes, Redox Biol.2025, 81, 103560.

A Far-Red Fluorescent Probe to Visualize Gram-positive Bacteria in Patient Samples

K. Jantarug, V. Tripathi, B. Morin, A. Iizuka, R. Kuehl, M. Morgenstern, M. Clauss, N. Khanna, D. Bumann, P. Rivera-Fuentes, ACS Infect. Dis.2024, 10, 1545.

Fluorogenic Polymethine Dyes by Intramolecular Cyclization.

A. Martin, P. Rivera-Fuentes, Curr. Op. Chem. Biol.2024, 80, 102444.

Revitalizing Antibiotic Discovery and Development Through in Vitro Modelling of In-Patient Conditions.

J. Sollier, M. Basler, P. Broz, P. S. Dittrich, K. Drescher, A. Egli, A. Harms, A. Hierlemann, S. Hiller, C. G. King, J. D. McKinney, J. Moran-Gilad, R. A. Neher, M. G. P. Page, S. Panke, A. Persat, P. Picotti, K. M. Rentsch, P. Rivera-Fuentes, U. Sauer, D. Stolz, S. Tschudin-Sutter, C. van Delden, E. van Nimwegen, J.-W. Veening, M. Zampieri, A. S. Zinkernagel, N. Khanna, D. Bumann, U. Jenal, C. Dehio. Nat. Microbiol.2024, 9, 1.

A General Strategy to Develop Fluorogenic Polymethine Dyes for Bioimaging.

A. Martin, P. Rivera-Fuentes, Nat. Chem.2024, 16, 28.

News & views article: Q. D Wilson, E. M. Sletten, Nat. Chem.2024, 16, 3. Engineering cyanine cyclizations for new fluorogenic probes.

A Locally Activatable Sensor for Robust Quantification of Organellar Glutathione.

S. Emmert, G. Quargnali, S. Thallmair, P. Rivera-Fuentes, Nat. Chem.2023, 15, 1415.

Highlighted in Chimia, 2023, 77, 620.

A Live-Cell Image-Based Machine Learning Strategy for Reducing Variability in PSC Differentiation Systems.

X. Yang, D. Chen, Q. Sun, Y. Wang, Y. Xia, J. Yang, C. Lin, X. Dang, Z. Cen, D. Liang, R. Wei, Z. Xu, G. Xi, G. Xue, C. Ye, L.-P. Wang, P. Zou, S.-Q. Wang, P. Rivera-Fuentes, S. Püntener, Z. Chen, Y. Liu, J. Zhang, Y. Zhao, Cell Discov.2023, 9, 53.

Multivalent Peptide Ligands To Probe the Chromocenter Microenvironment in Living Cells.

N. Guidotti, A. Eördögh, M. Mivelaz, P. Rivera-Fuentes, B. Fierz, ACS Chem. Biol. 2023, 18, 1066.

Single-Molecule Peptide Identification Using Fluorescence Blinking Fingerprints.

S. Püntener, P. Rivera-Fuentes, J. Am. Chem. Soc.2023, 145, 1441.

Watch here the explainer video!

Long-Term, Single-Molecule Imaging of Proteins in Live Cells with Photoregulated Fluxional Fluorophores.

A. Eördögh, A. Martin, P. Rivera-Fuentes, Chem. Eur. J.2022, 28, e202202832.

Rapid Characterization and Quantification of Extracellular Vesicles by Fluorescence-Based Microfluidic Diffusion Sizing.

C. Paganini, B. Hettich, M. R.G. Kopp, A. Eördögh, U. Capasso Palmiero, G. Adamo, N. Touzet, M. Manno, A. Bongiovanni, P. Rivera-Fuentes, J.-C. Leroux, P. Arosio, Adv. Healthcare Mater. 2022, 11, 210021.

Disruption of Mitochondrial Redox Homeostasis by Enzymatic Activation of a Trialkylphosphine Probe.

J. Nguyen, A. Tirla, P. Rivera-Fuentes, Org. Biomol. Chem. 2021, 19, 2681.

A Molecular Logic Gate Enables Single-Molecule Imaging and Tracking of Lipids in Intracellular Domains.

A. Eördögh, C. Paganini, D. Pinotsi, P. Arosio, P. Rivera-Fuentes, ACS Chem. Biol. 2020, 9, 2597.

Dual-Activatable Cell Tracker for Controlled and Prolonged Single-Cell Labeling.

E. A. Halabi, J. Arasa, S. Püntener, V. Collado-Diaz, C. Halin, P. Rivera-Fuentes, ACS Chem. Biol. 2020, 15, 1613.

Genetically Encoded Activators of Small Molecules for Imaging and Drug Delivery.

Z. Thiel, J. Nguyen, P. Rivera-Fuentes, Angew. Chem. Int. Ed.2020, 59, 7669.

The Bioorthogonal Isonitrile–Chlorooxime Ligation.

R. J. B. Schäfer, M. R. Monaco, M. Li, A. Tirla, P. Rivera-Fuentes, H. Wennemers, J. Am. Chem. Soc. 2019, 141, 18644.

Single-Molecule Imaging of Active Mitochondrial Nitroreductases Using a Photo-Crosslinking Fluorescent Sensor.

Z. Thiel, P. Rivera-Fuentes, Angew. Chem. Int. Ed.2019, 58, 11474.

Photoregulated Fluxional Fluorophores for Live-Cell Super-Resolution Microscopy with No Apparent Photobleaching.

E. A. Halabi, D. Pinotsi, P. Rivera-Fuentes, Nat. Commun.2019, 10, 1232.

Highlighted in Nat. Methods 2019, 16, 357.

Peptide Targeting of an Intracellular Receptor of the Secretory Pathway.

A. Tirla, P. Rivera-Fuentes, Biochemistry2019, 58, 1184.

Photochemically Active Dyes for Super-Resolution Microscopy.

Z. Thiel, P. Rivera-Fuentes, Chimia2018, 72, 764.

A Simple Probe for Super-Resolution Imaging of the Endoplasmic Reticulum in Living Cells.

E. A. Halabi, S. Püntener, P. Rivera-Fuentes, Helv. Chim. Acta2018, 101, e1800165.

Contribution to the special issue in honor of Prof. François Diederich.

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Synthesis of Asparagusic Acid Modified Lysine and its Application in Solid-Phase Synthesis of Peptides with Enhanced Cellular Uptake.

A. Tirla, M. Hansen, P. Rivera-Fuentes, Synlett2018, 29, 1289.

Invited contribution to the Special Section 9th Young Investigators Workshop (EuCheMS Organic Division).

Practical and Scalable Synthesis of 7-Azetidin-1-yl-4-(hydroxymethyl)coumarin: An Improved Photoremovable Group.

G. Bassolino, E. A. Halabi, P. Rivera-Fuentes, Synthesis2018, 50, 846.

Invited contribution to the Bürgenstock Special Section 2017 Future Stars in Organic Chemistry.

Photolabile Coumarins with Improved Efficiency through Azetidinyl Substitution.

G. Bassolino, C. Nançoz, Z. Thiel, E. Bois, E. Vauthey, P. Rivera-Fuentes, Chem. Sci.2018, 9, 387.

A Photoactivatable Probe for Super-Resolution Imaging of Enzymatic Activity in Live Cells.

E. A. Halabi, Z. Thiel, N. Trapp, D. Pinotsi, P. Rivera-Fuentes, J. Am. Chem. Soc.2017, 139, 13200.

Intracellular Photoactivation and Quantification using Fluorescence Microscopy: Chemical Tools and Imaging Approaches.

G. Bassolino, P. Rivera-Fuentes, Chimia2016, 70, 796.

Development of a Photoactivatable Phosphine Probe for Induction of Intracellular Reductive Stress with Single-Cell Precision.

A. Tirla, P. Rivera-Fuentes, Angew. Chem. Int. Ed.2016, 55, 14709.

Highlighted in Chimia.